Participants included patients with suspected or confirmed demyelinating diseases and healthy controls. Objective To investigate the frequency of MOG-IgA and associated clinical features in patients with demyelinating CNS disease and healthy controls.ĭesign, Setting, and Participants This longitudinal study comprised 1 discovery and 1 confirmation cohort derived from 5 centers. Yet little is known about the presence and clinical relevance of IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in CNS demyelination. In this regard, evidence suggests that immunoglobulin (Ig) A plays a role in the pathogenesis of different autoimmune diseases. Importance Differential diagnosis of patients with seronegative demyelinating central nervous system (CNS) disease is challenging. Siebenborn, MD 1,3,6,7 Rosa Cortese, MD, PhD 8 Sabine Schaedelin, PhD 1,3,6 Vinicius Andreoli Schoeps, MD, MPH 4 Aline de Moura Brasil Matos, MD 4,9 Natalia Trombini Mendes, MD 4 Clarissa dos Reis Pereira, MD 5 Mario Luiz Ribeiro Monteiro, MD, PhD 5 Samira Luisa dos Apóstolos-Pereira, MD, PhD 4 Patrick Schindler, MD 10,11,12 Claudia Chien, PhD 10,11,13 Carolin Schwake, MD 14 Ruth Schneider, MD 14 Thivya Pakeerathan, MD 14 Orhan Aktas, MD 15 Urs Fischer, MD 1 Matthias Mehling, MD 1,2,3 Tobias Derfuss, MD 1,2,3 Ludwig Kappos, MD 3,6 Ilya Ayzenberg, MD 14 Marius Ringelstein, MD 15,16 Friedemann Paul, MD 10,11,12 Dagoberto Callegaro, MD, PhD 4 Jens Kuhle, MD, PhD 1,2,3 Athina Papadopoulou, MD 1,3,6 Cristina Granziera, MD, PhD 1,3,6 Anne-Katrin Pröbstel, MD 1,2,3 Shared Decision Making and CommunicationĪna Beatriz Ayroza Galvão Ribeiro Gomes, MD 1,2,3,4 Laila Kulsvehagen, MSc 1,2,3 Patrick Lipps, MD 1,2,3 et al Alessandro Cagol, MD 1,3,6 Nuria Cerdá-Fuertes, MD 1 Tradite Neziraj, MD 1,2,3 Julia Flammer, MD 1,2,3 Jasmine Lerner 1,2,3 Anne-Catherine Lecourt, MSc 1,2,3 Nina de Oliveira S.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience. ![]() ![]() Challenges in Clinical Electrocardiography.
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